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It is estimated that between 300,000 and 750,000 people in the United States are suffering with ankylosing spondylitis (AS), with 75% of the cases being men, with symptoms typically presenting in their twenties.
Akylosing spondylitis is a hereditary auto-immune disease that causes chronic inflammation of the joints in the spine and the sacroiliac joing (where the spine joins with the pelvis). Eventually the joints of the spine may fuse together, causing immobility.
Prognosis of AS is difficult to predict, as the course of the disease can range from mild to very debilitating, and treatments are not always effective.