Depression Health Center
Depression impacts an estimated 15 million adults in the United States. Depression is a state of prolonged low mood and aversion to activity. A person's thoughts, behavior, feelings and physical well-being are affected and may include feelings of sadness, anxiety, emptiness, hopelessness, worthlessness, guilt, irritability, or restlessness.
The primary treatments for major depression are psychological counseling and medications.
Medication therapies include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), norepinephrine and dopamine reuptake inhibitors (NDRIs). SSRIs include: fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), citalopram (Celexa) and escitalopram (Lexapro). SNRIs include: duloxetine (Cymbalta), venlafaxine (Effexor) and desvenlafaxine (Pristiq). Bupropion (Wellbutrin) is an NDRI. Atypical antidepressants include trazodone (Desyrel) and mirtazapine (Remeron). Each medication category has different side effects.