Differin (generic: adapalene) is a prescription medication used to treat acne. Differin, a form of vitamin A, is thought to work by reducing inflammation and slowing the growth of keratin surface skin cells. This helps to unblock pores and decreases the formation of blackheads and pimples.

This medication comes in the form of a cream, a gel, and a lotion to be applied to the affected skin. It is usually applied once daily, at nighttime, after gently washing with a mild cleanser.

Common side effects include skin irritation, redness, peeling, and dryness.