Effexor treats depression. It may take several weeks before you feel the full benefit of this medication.

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Pharmacist Christine Wicke, PharmD overviews the uses and common side effects of Effexor
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Pharmacist Christine Wicke, PharmD overviews the uses and common side effects of Effexor
Pharmacist Lindsay Morrison, PharmD summarizes the uses, common side effects, and warnings for the Antidepressants class of medications

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Pill Images

24 HR Effexor 75 MG Extended Release Capsule
Color: Orange
Shape: Capsule
Size: 20.00
Score: 1
Imprint: W EffexorXR 75
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Effexor Cautionary Labels

Uses of Effexor


Effexor is a prescription medication used to treat adults with depression

This medication may be prescribed for other uses.  Ask your doctor or pharmacist for more information.


For more information on this medication choose from the list of selections below.

    Effexor Drug Class

    Effexor is part of the drug class:

    Side Effects of Effexor

    Effexor may cause serious side effects. See "Drug Precautions".

    Common side effects include:

    • constipation
    • dizziness
    • dry mouth
    • insomnia
    • loss of appetite
    • nausea
    • nervousness
    • sexual side effects
    • sleepiness
    • sweating
    • weakness

    This is not a complete list of Effexor side effects. Ask your doctor or pharmacist for more information.

    Effexor Interactions

    Tell your doctor about all the medicines you are taking including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you are taking:

    • MAO inhibitor
    • Alcohol 
    • Fluoxetine 
    • Citalopram 
    • Sertraline 
    • Amitriptyline 
    • Doxepin 
    • Phenelzine 
    • Isocarboxzid 
    • Lithium 
    • Tramadol 
    • Indinavir 
    • Ketoconazole 
    • Cimetidine

    This is not a complete list of Effexor drug interactions. Ask your doctor or pharmacist for more information.

    Effexor Precautions

    1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.

    2. Depression and other serious mental illnesses are the most important causes of suicidal thoughts and actions. Some people may have a particularly high risk of having suicidal thoughts or actions. These include people who have (or have a family history of) bipolar illness (also called manic-depressive illness) or suicidal thoughts or actions.

    3. How can I watch for and try to prevent suicidal thoughts and actions in myself or a family member?

    • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is very important when an antidepressant medicine is started or when the dose is changed.
    • Call the healthcare provider right away to report new or sudden changes in mood, behavior, thoughts, or feelings.
    • Keep all follow-up visits with the healthcare provider as scheduled. Call the healthcare provider between visits as needed, especially if you have concerns about symptoms.

    Do not take Effexor if:

    • you have taken an MAO inhibitor in the last 2 weeks
    • you have a history of mania, seizures, or kidney problems

    Effexor may make you drowsy. Do not drive or operate heavy machinery until you know how this medication affects you.

    Effexor Food Interactions

    Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Effexor there are no specific foods that you must exclude from your diet when receiving Effexor.

    Inform MD

    Before receiving this medication, tell your doctor about all your medical conditions especially:

    • bipolar disorder
    • heart disease or high blood pressure
    • epilepsy
    • glaucoma
    • liver or kidney disease
    • blood clotting disorder (bleeding disorder)

    Tell your doctor about all the medicines you take or are planning to take including prescription and non-prescription medicines, vitamins, and herbal supplements.

    Tell your doctor if you are pregnant, planning to become pregnant or breastfeeding.

    Effexor and Pregnancy

    Tell your doctor if you are pregnant or plan to become pregnant.

    The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

    This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

    Effexor and Lactation

    Tell your doctor if you are breastfeeding or planning to breastfeed. Effexor may be excreted in human breast milk and may harm your nursing baby.

    Effexor Usage

    Effexor tablets or capsules should be taken with food, at the same time(s) each day.

    Do not suddenly stop taking Effexor without talking to your doctor first. Abruptly stopping Effexor can cause withdrawal symptoms (unpleasant side effects).

    If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Effexor at the same time.

    Effexor Dosage

    Take Effexor exactly as your doctor prescribes it. Follow the directions on your prescription label carefully. The dose will depend on several factors including the condition being treated, response to the medicine, and how well the medicine is tolerated.

    The usual starting dose of Effexor is 75 mg per day, divided into two or three doses. Some patients will need to be started on 37.5 mg per day and after 4 to 7 days increased to 75 mg per day. Dose increases of up to 75 mg per day may be necessary.

    The recommended maximum daily dose is 225 mg, although some patients may require as much as 350 mg per day.

    Effexor Overdose

    If you take too much Effexor call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

    If Effexor is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

    Other Requirements

    • Store at controlled room temperature.
    • Keep all medications out of the reach of children.

    Effexor FDA Warning

    Suicidality and Antidepressant Drugs

    Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of Effexor or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Effexor is not approved for use in pediatric patients.