Lamictal (lamotrigine) is an oral medication used primarily to treat epilepsy and Lennox-Gastaut syndrome (a disorder that causes seizures and sometimes developmental delays). It is also used to extend the time between depressive and manic episodes in bipolar disorder, although it does not treat these episodes.

It is part of a class of medications called anticonvulsants. It works by affecting the electrical activity in the brain. The goal of an anticonvulsant is to suppress the rapid and excessive firing of neurons that start a seizure.

Lamictal has been used off-label for the treatment of peripheral neuropathy, trigeminal neuralgia, cluster headaches, migraines, and reducing neuropathic pain.

Off-label psychiatric usage includes the treatment of depersonalization disorder, bipolar II disorder and other bipolar disorders, schizoaffective disorder, borderline personality disorder and post-traumatic stress disorder.