Lioresal (generic: baclofen) is a prescription medication used to relieve spasms and increased muscle tone caused by multiple sclerosis or spinal injury. This medication belongs to a group of drugs called muscle relaxants. Although the way it works is not fully understood, Lioresal may decrease the number and severity of muscle spasms by inhibiting nerve signals.

This medication comes in tablet form and as an injectable liquid to be given directly into the spinal fluid. Lioresal tablets are usually taken 3 or 4 times daily, with or without food.

Common side effects include weakness, drowsiness, and dizziness. Do not drive or operate machinery until you know how this medication affects you.

*Brand name Lioresal tablets are no longer available. Generic versions (baclofen) are made available by several manufacturers.