Liptruzet (generic: ezetimibe/atorvastatin) is a prescription medication, used in combination with diet and exercise, to treat high cholesterol. It is also used to lower cholesterol in people with homozygous familial hypercholesterolemia (HoFH, a hereditary disorder that causes high cholesterol levels).

Liptruzet is a single tablet containing two prescription medicines, ezetimibe and atorvastatin. Ezetimibe belongs to a group of drugs called cholesterol absorption inhibitors, which block the absorption of cholesterol from the intestines. Atorvastatin belongs to a group of drugs called HMG-CoA reductase inhibitors, also known as statins, which block an enzyme in the body called HMG-CoA reductase. This is a major enzyme involved in making cholesterol in the body.

Liptruzet is available as a once-daily tablet containing 10 mg of ezetimibe combined with 10, 20, 40, or 80 mg of atorvastatin. It can be taken at any time of day, with or without food.

Common side effects during clinical trial included elevated enzymes (ALT and AST), and musculoskeletal pain.