Methotrexate is a prescription medication used to treat certain types of cancer including breast cancer, head and neck cancer, lung cancer, lymphoma, leukemia, and skin cancer. It is also used to treat psoriasis and rheumatoid arthritis. Methotrexate belongs to a group of drugs called antimetabolites which decrease the activity of the immune system and slow the growth of cancer cells.

This medication comes in tablet and injectable forms. Methotrexate tablets can be taken with or without food.

Common side effects of methotrexate include nausea, dizziness, drowsiness, and headache.