Natazia (generic: estradiol/dienogest) is a prescription medication used to prevent pregnancy. Natazia contains two medications, an estrogen (estradiol) and a progestin (dienogest) which belong to a group of drugs called hormonal contraceptives. These hormones prevent pregnancy by stopping ovulation, and by altering cervical mucus and the lining of the uterus. 

Natazia is the first four-phase oral contraceptive (birth control pill). Four-phasic means the doses of estrogen and progestin vary four times throughout each 28-day cycle.

This medication comes in a packet of 28 tablets. It is taken once daily, at the same time every day, for 28 days and then a new pack is started. Natazia tablets can be taken with or without food.

Common side effects of Natazia include headaches, nausea, and spotting or bleeding between menstrual periods.