Orencia (generic: abatacept) is a prescription medication used to treat rheumatoid arthritis. Orencia belongs to a group of drugs called immunomodulators which work by blocking the activity of T-cells, a cell of the immune cell that can cause swelling and joint damage in rheumatoid arthritis.

This medication comes in an injectable form that is usually given directly into a vein (IV) by a healthcare provider. Orencia may also be given as an injection just under the skin.

Common side effects of Orencia include headache, upper respiratory tract infection, sore throat, and nausea.