Premarin Vaginal Cream (generic: conjugated estrogens) is a prescription medication used to treat changes in and around the vagina because of menopause. Premarin belongs to a group of drugs called estrogen derivatives, which help raise your estrogen levels.

This medication comes in the form of a cream to be applied vaginally using an applicator.

Common side effects of Premarin Vaginal Cream include headache, breast pain, and irregular vaginal bleeding.