Premarin is a medicine that contains a mixture of estrogen hormones. It is used to treat hot flushes (hot flashes; sudden strong feelings of heat and sweating) and/or vaginal dryness, itching, and burning in women who are experiencing menopause (change of life; the end of monthly menstrual periods).

Premarin comes as a liquid to inject into a muscle.  These medications are usually injected by a health care professional once every 3-4 weeks.

Some common side effects of Premarin include breast pain or tenderness, upset stomach, vomiting, depression, weight loss and dizziness.