Prolia Overview

Prolia (generic: denosumab) is a prescription medicine used to treat osteoporosis (thinning and weakening of bone) in women after menopause who cannot take other osteoporosis medications. It is also used in people who have tried other osteoporosis medications without success, and in people who have bone loss caused by cancer treatments. Prolia belongs to a group of drugs called RANK ligand inhibitors. It works by slowing production and activity of osteoclasts (bone cells that cause bone breakdown).

Prolia comes in an injectable form to be given just under the skin by a healthcare provider. Prolia is usually given as a single injection every 6 months.  Patients receiving Prolia should also take calcium and vitamin D supplements every day.

Common side effects of Prolia include back pain, muscle pain, and pain in the arms and legs.