Symbyax (generic: olanzapine/fluoxetine) is a prescription medication used to treat depression for which other treatments have not worked. It is also used to treat depression linked to bipolar disorder. It is a single capsule containing two medications, olanzapine and fluoxetine. Olanzapine belongs to a group of drugs called antipsychotics and fluoxetine is an antidepressant. Together these drugs affect brain chemicals involved in maintaining mental balance and regulating mood.