Tofranil (generic: imipramine) is a prescription medication used to treat the symptoms of depression and to prevent bedwetting in children. This medication belongs to a group of drugs called tricyclic antidepressants (TCAs), which treat the symptoms of depression by adjusting the levels of natural chemicals in the brain. The exact way Tofranil works to prevent bedwetting is unknown.

Tofranil comes in tablet and capsule forms and may be taken once or several times a day, depending on your doctor’s instructions. When Tofranil tablets are used to prevent bedwetting in children, they are usually taken one hour before bedtime, or as one dose in the afternoon and another dose at bedtime.

Common side effects include nausea, weakness and dry mouth. Tofranil can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you.