Treximet (generic: sumatriptan/naproxen) is a prescription medication used to treat migraines in adults. Treximet comes as a tablet containing two prescription drugs.  Sumatriptan belongs to a group of drugs called selective serotonin receptor agonists or "triptans", which narrow blood vessels in the head and prevent pain signals in the brain.  Naproxen belongs to a group of drugs called non-steroidal anti-inflammatory drugs (NSAID), which prevent pain and inflammation.

This medication comes in tablet form. One tablet is taken at the first sign of a migraine headache, with or without food.  A second tablet may be taken after 2 hours if needed.

Common side effects of Treximet include drowsiness, diarrhea, and pain in the chest, neck, throat, or stomach.