Zaltrap (generic: ziv-aflibercept) is a prescription medication used along with other medications to treat cancer of the colon or rectum that has spread to other parts of the body. Zaltrap belongs to a group of drugs called antiangiogenic agents. It works by inhibiting the growth of new blood vessels that bring oxygen and nutrients to tumors. Without nutrients, growth and spread of tumors is slowed.

This medication comes in an injectable form to be given directly into a vein (IV) by a healthcare provider. Zaltrap is usually given once every 14 days.

Common side effects of Zaltrap include decreased white blood cell count, tiredness, mouth ulcers, and diarrhea.