Zaroxolyn (generic: metolazone) is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure or kidney disease. This medication belongs to a group of drugs called diuretics ("water pills"), which help the body get rid of excess fluid  by increasing the amount of salt and water the kidneys remove from the blood.

This medication comes in tablet form and is usually taken once daily. Zaroxolyn can be taken with or without food.

Common side effects of Zaroxolyn include headache, stomach pain, and dry mouth. Zaroxolyn may cause drowsiness. Do not drive or operate heavy machinery until you know how it affects you.