Zometa (generic: zoledronic acid) is a prescription medication used to treat high blood calcium caused by cancer, and to prevent or delay bone problems due to cancer.  Zometa belongs to a group of drugs called biphosphonates, which slow the breakdown of bone. 

This medication comes in an injectable form to be given directly into a vein (IV) by a healthcare provider. For high blood calcium Zometa is given once. For bone problems caused by cancer, it may given every 3 or 4 weeks for as long as 24 months.

Common side effects of Zometa include fever, nausea, bone pain, and fatigue.