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Esophageal Cancer

Getting Help

Every cancer diagnosis is different, just as every person who is diagnosed with cancer is different. Cancer knows no barriers to race, age, or social group. However there is one thing that each and every person who is diagnosed with cancer will have in common: help with fighting and beating the disease.

Life after being diagnosed with cancer will be different for everyone. Some people will have minimal disease and it will be a short chapter of their lives, while others will have a diagnosis that will change the course of the rest of their lives. Cancer diagnoses can change relationships, your routines, your work and home life. One thing is certain, no one person’s experience will be exactly the same. There are however, plenty of resources to learn about what life was like for other people, and what they did to achieve balance, maintain their health and personal life, keep peace of mind, and enjoy their lives with or after cancer.

Clinical Trials

The search for a cure for cancer is an ongoing, constant battle. Clinical trials are the basis upon which new treatments and medications are proven to help the fight against cancer, or if researchers should pursue another tactic. The advancement of medicine depends on willing and able cancer patients to volunteer for experimental treatments so that future generations will have proven and effective cures. Not every patient with cancer will be eligible for a clinical trial, as the scientific method needs specific patients with specific types of cancers. However, patients who are selected for trials may benefit from being at the cutting edge of new research, and gain time they otherwise might not have had.

The National Cancer Institute at the National Institutes of Health has a comprehensive database of over 10,000 ongoing clinical trials that both help advance medicine and help patients.

Financial Help

Unfortunately, cancer treatment can be costly, even if a patient has very comprehensive health insurance. For patients who do not have health insurance, the cost of treatment may seem insurmountable. Fortunately many pharmaceutical companies offer cost assistance to help make treatment more affordable. The National Comprehensive Cancer Network has compiled a Virtual Reimbursement Room where patients can find information for accessing financial help with their treatment costs.

Living With

Life after being diagnosed with cancer will be different for everyone. Some people will have minimal disease and it will be a short chapter of their lives, while others will have a diagnosis that will change the course of the rest of their lives. Cancer diagnoses can change relationships, your routines, your work and home life. One thing is certain, no one person’s experience will be exactly the same. There are however, plenty of resources to learn about what life was like for other people, and what they did to achieve balance, maintain their health and personal life, keep peace of mind, and enjoy their lives with or after cancer.

Your experience with cancer will depend on the type of cancer you have, your choices of treatment and the lifestyle you lead. Be sure to speak with your Doctor about the side effects of your disease and the treatments you choose. Your Doctor will be able to consult with you on realistic lifestyle expectations. 

Causes

Studies have found the following risk factors for esophageal cancer:

  • Age 65 or older: Age is the main risk factor for esophageal cancer. The chance of getting this disease goes up as you get older. In the United States, most people are 65 years of age or older when they are diagnosed with esophageal cancer.
  • Being male: In the United States, men are more than three times as likely as women to develop esophageal cancer.
  • Smoking: People who smoke are more likely than people who don’t smoke to develop esophageal cancer.
  • Heavy drinking: People who have more than 3 alcoholic drinks each day are more likely than people who don’t drink to develop squamous cell carcinoma of the esophagus. Heavy drinkers who smoke are at a much higher risk than heavy drinkers who don’t smoke. In other words, these two factors act together to increase the risk even more.
  • Diet: Studies suggest that having a diet that’s low in fruits and vegetables may increase the risk of esophageal cancer. However, results from diet studies don’t always agree, and more research is needed to better understand how diet affects the risk of developing esophageal cancer.
  • Obesity: Being obese increases the risk of adenocarcinoma of the esophagus.
  • Acid reflux: Acid reflux is the abnormal backward flow of stomach acid into the esophagus. Reflux is very common. A symptom of reflux is heartburn, but some people don’t have symptoms. The stomach acid can damage the tissue of the esophagus. After many years of reflux, this tissue damage may lead to adenocarcinoma of the esophagus in some people.
  • Barrett esophagus: Acid reflux may damage the esophagus and over time cause a condition known as Barrett esophagus. The cells in the lower part of the esophagus are abnormal. Most people who have Barrett esophagus don’t know it. The presence of Barrett esophagus increases the risk of adenocarcinoma of the esophagus. It’s a greater risk factor than acid reflux alone.

Many other possible risk factors (such as smokeless tobacco) have been studied. Researchers continue to study these possible risk factors. Having a risk factor doesn’t mean that a person will develop cancer of the esophagus. Most people who have risk factors never develop esophageal cancer.

Diagnosis

If you have a symptom that suggests esophageal cancer, your doctor must find out whether it’s really due to cancer or to some other cause. The doctor gives you a physical exam and asks about your personal and family health history. You may have blood tests. You also may have:

  • Barium swallow: After you drink a barium solution, you have x-rays taken of your esophagus and stomach. The barium solution makes your esophagus show up more clearly on the x-rays. This test is also called an upper GI series.
  • Endoscopy: The doctor uses a thin, lighted tube (endoscope) to look down your esophagus. The doctor first numbs your throat with an anesthetic spray, and you may also receive medicine to help you relax. The tube is passed through your mouth or nose to the esophagus. The doctor may also call this procedure upper endoscopy, EGD, or esophagoscopy.
  • Biopsy: Usually, cancer begins in the inner layer of the esophagus. The doctor uses an endoscope to remove tissue from the esophagus. A pathologist checks the tissue under a microscope for cancer cells. A biopsy is the only sure way to know if cancer cells are present.
Overview

Esophageal cancer begins in cells in the inner layer of the esophagus. Over time, the cancer may invade more deeply into the esophagus and nearby tissues.

Cancer cells can spread by breaking away from the original tumor. They may enter blood vessels or lymph vessels, which branch into all the tissues of the body. The cancer cells may attach to other tissues and grow to form new tumors that may damage those tissues. The spread of cancer cells is called metastasis. See the Staging section for information about esophageal cancer that has spread.

Growths in the wall of the esophagus can be benign (not cancer) or malignant (cancer). The smooth inner wall may have an abnormal rough area, an area of tiny bumps, or a tumor. Benign growths are not as harmful as malignant growths:

Benign growths:

  • are rarely a threat to life
  • can be removed and probably won’t grow back
  • don’t invade the tissues around them
  • don’t spread to other parts of the body

Malignant growths:

  • may be a threat to life
  • sometimes can be removed but can grow back
  • can invade and damage nearby tissues and organs
  • can spread to other parts of the body
Symptoms

Early esophageal cancer may not cause symptoms. As the cancer grows, the most common symptoms are:

  • Food gets stuck in the esophagus, and food may come back up
  • Pain when swallowing
  • Pain in the chest or back
  • Weight loss
  • Heartburn
  • A hoarse voice or cough that doesn’t go away within 2 weeks

These symptoms may be caused by esophageal cancer or other health problems. If you have any of these symptoms, you should tell your doctor so that problems can be diagnosed and treated as early as possible.

Treatments

People with esophageal cancer have several treatment options. The options are surgery, radiation therapy, chemotherapy, or a combination of these treatments. For example, radiation therapy and chemotherapy may be given before or after surgery.

Surgery

There are several types of surgery for esophageal cancer. The type depends mainly on where the cancer is located. The surgeon may remove the whole esophagus or only the part that has the cancer. Usually, the surgeon removes the section of the esophagus with the cancer, lymph nodes, and nearby soft tissues. Part or all of the stomach may also be removed. You and your surgeon can talk about the types of surgery and which may be right for you.

Radiation Therapy

Radiation therapy (also called radiotherapy) uses high-energy rays to kill cancer cells. It affects cells only in the treated area.

Radiation therapy may be used before or after surgery or it may be used instead of surgery. Radiation therapy is usually given with chemotherapy to treat esophageal cancer.

Doctors use two types of radiation therapy to treat esophageal cancer. Some people receive both types:

  • External radiation therapy: The radiation comes from a large machine outside the body. The machine aims radiation at your cancer. You may go to a hospital or clinic for treatment. Treatments are usually 5 days a week for several weeks.
  • Internal radiation therapy (brachytherapy): The doctor numbs your throat with an anesthetic spray and gives you medicine to help you relax. The doctor puts a tube into your esophagus. The radiation comes from the tube. Once the tube is removed, no radioactivity is left in your body. Usually, only a single treatment is done.

Chemotherapy

Most people with esophageal cancer get chemotherapy. Chemotherapy uses drugs to destroy cancer cells. The drugs for esophageal cancer are usually given through a vein (intravenous). You may have your treatment in a clinic, at the doctor’s office, or at home. Some people need to stay in the hospital for treatment.

Chemotherapy is usually given in cycles. Each cycle has a treatment period followed by a rest period.

Related Information

Doctors all over the country are conducting many types of clinical trials (research studies in which people volunteer to take part). Clinical trials are designed to answer important questions and to find out whether new approaches are safe and effective. Research already has led to advances that have helped people live longer, and research continues. Doctors are trying to find better ways to care for people with esophageal cancer:

  • Surgery: Surgeons are studying whether small cuts can be used instead of long incisions. The surgeon makes small cuts in the neck, chest, and abdomen. The surgeon sees inside the chest with a laparoscope, and the cancer-containing esophagus is removed.
  • Chemotherapy and biological therapy: NCI is sponsoring a study of biological therapy (a monoclonal antibody) combined with chemotherapy.
  • Supportive care: Doctors are also testing ways to manage the problems caused by cancer and its treatment.

Even if the people in a trial do not benefit directly, they may still make an important contribution by helping doctors learn more about cancer and how to control it. Although clinical trials may pose some risks, doctors do all they can to protect their patients.