Do not drive a car, work with machines, or do other dangerous activities until you know how Lyrica affects you.
Do not drink alcohol while taking Lyrica. Lyrica and alcohol can affect each other and increase side effects such as sleepiness and dizziness.
Lyrica is a prescription medicine used in adults, 18 years and older, to treat:
- Pain from damaged nerves (neuropathic pain) that happens with diabetes
- Pain from damaged nerves (neuropathic pain) that follows healing of shingles
- Partial seizures when taken together with other seizure medicines
- Fibromyalgia (pain all over your body)
Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known if Lyrica is excreted in human breast milk or if it will harm your nursing baby.
- Store Lyrica capsules and oral solution at room temperature, 59°F to 86°F (15°C to 30°C) in its original package.
- Safely throw away any Lyrica that is out of date or no longer needed.
- Keep Lyrica and all medicines out of the reach of children.
Lyrica (pregabalin) is an oral medication used primarily to treat neuropathic pain (pain from damaged nerves) resulting from diabetes and shingles. Other uses include treatment of pain from fibromyalgia and is also used along with other medications to treat seizures. It is part of a class of medications called anticonvulsants, and works by decreasing the release of pain neurotransmitters in the brain.
Lyrica works by binding to the proteins in the brain called calcium channels that help conduct electrical communication. By doing so, it acts to decrease the release of the neurotransmitters glutamate, norepinephrine, and substance P, all of which acts to decrease pain sensation.
Lyrica may cause serious side effects including:
- Serious, even life-threatening, allergic reactions
- Suicidal thoughts or actions
- Swelling of your hands, legs and feet
- Dizziness and sleepiness
These serious side effects are described below:
- 1. Serious, even life-threatening, allergic reactions.
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- Stop taking Lyrica and call your healthcare provider right away if you have any of these signs of a serious allergic reaction:
- swelling of your face, mouth, lips, gums, tongue, throat or neck
- trouble breathing
- rash, hives (raised bumps) or blisters
- 2. Like other antiepileptic drugs, Lyrica may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.
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- Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
- thoughts about suicide or dying
- attempts to commit suicide
- new or worse depression
- new or worse anxiety
- feeling agitated or restless
- panic attacks
- trouble sleeping (insomnia)
- new or worse irritability
- acting aggressive, being angry, or violent
- acting on dangerous impulses
- an extreme increase in activity and talking (mania)
- other unusual changes in behavior or mood
- If you have suicidal thoughts or actions, do not stop Lyrica without first talking to a healthcare provider.
- Stopping Lyrica suddenly can cause serious problems.
- Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.
- How can I watch for early symptoms of suicidal thoughts and actions?
- Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.
- Keep all follow-up visits with your healthcare provider as scheduled.
- Call your healthcare provider between visits as needed, especially if you are worried about symptoms.
- 3. Swelling of your hands, legs and feet. This swelling can be a serious problem for people with heart problems.
- 4. Dizziness and sleepiness.
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Do not drive a car, work with machines, or do other dangerous activities until you know how Lyrica affects you. Ask your healthcare provider about when it will be okay to do these activities.
Do not take Lyrica if you are allergic to pregabalin or any of the ingredients in Lyrica.
Do not drink alcohol while taking Lyrica.
In case of overdose, seek medical attention.
- Take Lyrica exactly as prescribed. Your doctor will tell you how much Lyrica to take and when to take it. Take Lyrica at the same times each day.
- Lyrica may be taken with or without food.
- Your doctor may change your dose. Do not change your dose without talking to your doctor.
- Do not stop taking Lyrica without talking to your doctor. If you stop taking Lyrica suddenly you may have headaches, nausea, diarrhea or trouble sleeping. If you have epilepsy and you stop taking Lyrica suddenly, you may have seizures more often. Talk with your doctor about how to stop Lyrica slowly.
- If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take two doses at the same time.
- If you take too much Lyrica, call your doctor or poison control center, or go to the nearest emergency room right away.
Take Lyrica exactly as prescribed. Your healthcare provider will tell you how much Lyrica to take and when to take it. Take Lyrica at the same times each day. Lyrica may be taken with or without food.
Your healthcare provider may change your dose. Do not change your dose without talking to your healthcare provider.Do not stop taking Lyrica without talking to your healthcare provider. If you stop taking Lyrica suddenly you may have headaches, nausea, diarrhea or trouble sleeping. If you have epilepsy and you stop taking Lyrica suddenly, you may have seizures more often. Talk with your healthcare provider about how to stop Lyrica slowly.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take two doses at the same time.
Tell your doctor if you are pregnant or planning to become pregnant. It is not known if Lyrica will harm your unborn baby.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Lyrica and other medicines may affect each other. Always check with your doctor before starting or stopping any medicines. Especially tell your doctor if you take:
- angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril (Capoten, in Capozide), enalapril (Vasotec, in Vaseretic, Lexxel), fosinopril (Monopril), lisinopril (Prinivil, Zestril, in Prinzide, Zestoretic), moexipril (Univasc, in Uniretic), perindopril (Aceon), quinapril (Accupril, in Accuretic, Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka)
- antidepressants
- antihistamines
- medications for anxiety, including lorazepam (Ativan)
- medications for mental illness or seizures
- certain medications for diabetes such as pioglitazone (Actos, in Duetact) and rosiglitazone (Avandia, in Avandaryl, Avandamet)
- narcotic pain medications, including oxycodone (OxyContin, in Percocet, others)
- sedatives
- sleeping pills
- tranquilizers
This is not a complete list of Lyrica drug interactions. Ask your doctor or pharmacist for more information.
Take Lyrica exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you.
The recommended dosage varies depending upon the patient’s kidney function (creatinine clearance) and the medical condition being treated. Initial dosages are often 150 mg per day in divided doses (smaller doses taken two or three times daily) and are gradually increased to a maximum dose of 600 mg per day.
Lyrica is a prescription medicine used in adults, 18 years and older, to treat:
- pain from damaged nerves (neuropathic pain) that happens with diabetes
- pain from damaged nerves (neuropathic pain) that follows healing of shingles
- partial seizures when taken together with other seizure medicines
- fibromyalgia (pain all over your body)
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Before taking Lyrica, tell your healthcare provider about all the medicines you take and your medical conditions, including if you:
- are allergic to Lyrica
- have or have had depression, mood problems or suicidal thoughts or behavior
- have kidney problems or get kidney dialysis
- have heart problems including heart failure
- have a bleeding problem or a low blood platelet count
- have abused prescription medicines, street drugs, or alcohol in the past
- have ever had swelling of your face, mouth, tongue, lips, gums, neck, or throat (angioedema)
- plan to father a child (Lyrica has caused decreased fertility in male animals and birth defects in offspring of animals treated)
- are pregnant or planning to become pregnant
The most common side effects of Lyrica are:
- Dizziness
- Blurry vision
- Weight gain
- Sleepiness
- Trouble concentrating
- Swelling of hands and feet
- Dry mouth
Lyrica may cause serious side effects, including:
- Muscle problems, muscle pain, soreness, or weakness. If you have these symptoms, especially if you feel sick and have a fever, tell your healthcare provider right away.
- Problems with your eyesight, including blurry vision. Call your healthcare provider if you have any changes in your eyesight.
- Weight gain. If you have diabetes, weight gain may affect the management of your diabetes. Weight gain can also be a serious problem for people with heart problems.
- Feeling “high”
Lyrica may also cause serious, even life-threatening, allergic reactions.
Stop taking Lyrica and call your healthcare provider right away if you have any of these signs of a serious allergic reaction:
- Swelling of your face, mouth, lips, gums, tongue, throat or neck
- Trouble breathing
- Rash, hives (raised bumps) or blisters
Like other antiepileptic drugs, Lyrica may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.
Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
- Thoughts about suicide or dying
- Attempts to commit suicide
- New or worse depression
- New or worse anxiety
- Feeling agitated or restless
- Panic attacks
- Trouble sleeping (insomnia)
- New or worse irritability
- Acting aggressive, being angry, or violent
- Acting on dangerous impulses
- An extreme increase in activity and talking (mania)
- Other unusual changes in behavior or mood
If you have suicidal thoughts or actions, do not stop Lyrica without first talking to a healthcare provider.
- Stopping Lyrica suddenly can cause serious problems
- Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes
Lyrica may cause swelling of your hands, legs and feet. This swelling can be a serious problem for people with heart problems.
Lyrica may cause dizziness and sleepiness.
Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of Lyrica there are no specific foods that you must exclude from your diet when receiving Lyrica.
Lyrica capsules are available in 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, and 300 mg strengths.
Active ingredient: pregabalin
Inactive ingredients:
Lyrica capsules: lactose monohydrate, cornstarch, talc
Capsule shell: gelatin and titanium dioxide; Orange capsule shell: red iron oxide; White capsule shell: sodium lauryl sulfate, colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells.
Imprinting ink: shellac, black iron oxide, propylene glycol, potassium hydroxide.
Lyrica oral solution is available in a 20 mg/mL solution.
Lyrica oral solution: methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water.