This medication can be taken orally or through the nasogastric tube or gastric tube route. Nymalize should NOT be given intravenously or by other parenteral routes.
Begin Nymalize within 96 hours of the onset of SAH. Take one hour before a meal or two hours after a meal.
How to give Nymalize via a nasogastric tube or gastric tube:
Using the supplied oral syringe labeled “ORAL USE ONLY”, administer 20 mL (60 mg) every 4 hours into a nasogastric or gastric tube for 21 consecutive days. For each dose, refill the syringe with 20 mL of 0.9% saline solution and then flush any remaining contents from nasogastric or gastric tube into the stomach.
Before taking Nymalize, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- have liver problems
- have kidney problems
- have heart problems
- are pregnant or breastfeeding
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
Tell your doctor if you are pregnant or plan to become pregnant.
The FDA categorizes medications based on safety for use during pregnancy. Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
Nymalize falls into category C.
There are no well-controlled studies in pregnant women. Nymalize should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
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some macrolide antibiotics such as clarithromycin, and telithromycin
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some HIV protease inhibitors such as indinavir, nelfinavir, ritonavir, and saquinavir
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some HCV protease inhibitors such as boceprevir and telaprevir
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some azole antimycotics such as ketoconazole, itraconazole, posaconazole, and voriconazole
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conivaptan
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delaviridine
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nefazadone
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carbamazepine
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phenobarbital
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phenytoin
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rifampin
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St John’s wort
This is not a complete list of Nymalize drug interactions. Ask your doctor or pharmacist for more information.
Nymalize is available as 60 mg/20 mL oral (by mouth) solution.
Tell your doctor if you are breastfeeding or plan to breastfeed.
It is not known if Nymalize crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Nymalize.
If you take too much Nymalize, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.
Serious side effects have been reported with Nymalize. See “Drug Precautions” section.
The most common side effects reported in clinical trials include:
- decreased blood pressure
- headache
- nausea
- slower than normal heartbeat
- rash
This is not a complete list of Nymalize side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Grapefruit and grapefruit juice may interact with Nymalize and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Nymalize is a prescription medication used to treat patients experiencing symptoms resulting from ruptured blood vessels in the brain (subarachnoid hemorrhage).
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
The recommended oral dosage is 20 mL (60 mg) every 4 hours for 21 consecutive days.
For people with cirrhosis (scarring of the liver), the dose is reduced to 10 mL (30 mg) every 4 hours.
Nymalize (generic: nimodipine) is a prescription medicine used to treat patients experiencing symptoms resulting from ruptured blood vessels in the brain (subarachnoid hemorrhage). Subarachnoid hemorrhage is serious, life threatening bleeding that occurs in the subarachnoid space – the area between the brain and the thin tissues that cover the brain. Nimodipine is a medication given in a critical care setting to treat neurologic complications from subarachnoid hemorrhage.
Store at room temperature between 15ºC to 30ºC (59ºF to 86ºF).
Protect from light.
Do not refrigerate.
Keep this and all medications out of the reach of children.
Serious side effects have been reported with Nymalize including:
- Nymalize can cause decreased blood pressure (hypotension). Your healthcare provider will carefully monitor your blood pressure during treatment.
- People with cirrhosis (scarring of the liver) are at an increased risk of serious side effects.