Trilafon is a prescription medication used to treat schizophrenia and to control severe nausea and vomiting in adults.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
WARNING
Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Perphenazine is not approved for the treatment of patients with dementia-related psychosis.
Trilafon (generic: perphenazine) is a prescription medication used to treat schizophrenia and to control severe nausea and vomiting in adults. Trilafon belongs to a group of drugs called first generation or “typical” antipsychotics. The exact way it works is unknown, however it is thought to work by affecting certain chemicals in the brain.
Trilafon comes in tablet form. It is usually taken 2 to 4 times daily.
Common side effects include dry mouth, blurred vision, drowsiness, and dizziness. Do not drive or operate heavy machinery until you know how it affects you.
*Brand name Trilafon tablets are no longer available. Generic versions are made available by several manufacturers.
Common side effects include:
- drowsiness
- dizziness
- blurred vision
- dry mouth
- excess saliva
- stuffed nose
- headache
- nausea
- vomiting
- diarrhea
- constipation
- loss of appetite
- unusual, slowed, or uncontrollable movements of any part of the body
- restlessness
- difficulty falling asleep or staying asleep
- difficult or frequent urination
- breast enlargement
- breast milk production
- impotence
This is not a complete list of Trilafon side effects. Ask your doctor or pharmacist for more information.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.